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Vitamin D plus calcium may protect everyone from fracture: Study
By Stephen Daniells, 15-Jan-2010
Related topics: Research, Minerals, Vitamins & premixes, Bone & joint health
Daily supplements which combine vitamin D and calcium may reduce the risk of fractures for everyone, regardless of age or gender, say the results of a huge study.
Almost 70,000 people participated in the US and Europe and found that the vitamin-mineral combination significantly reduced fractures by 8 per cent, and hip fractures by 16 per cent, according to results of a pooled analysis published in the British Medical Journal.
However, supplemental vitamin D on its own in daily doses equivalent to 10 to 20 micrograms had no effects on fracture prevention, said the study, led by researchers at Copenhagen University in Denmark.
“What is important about this very large study is that goes a long way toward resolving conflicting evidence about the role of vitamin D, either alone or in combination with calcium, in reducing fractures,” said co-author of the study, Professor John Robbins from the University of California, Davis.
History of use
The combination of vitamin D and calcium has long been recommended to reduce the risk of bone fracture for older people, particularly those at risk of or suffering from osteoporosis, which is estimated to affect about 75m people in Europe, USA and Japan.
The action of the nutrients is complimentary, with calcium supporting bone formation and repair, while vitamin D helps the body absorb calcium.
The new study reports that the bone boosting effects of vitamin D plus calcium may also extend to other age groups and to both sexes.
Study details
The researchers used data from seven major randomized trials of vitamin D with calcium or vitamin D alone, providing data from 68,517 people. The average age of the participants was 69.9, and 15 per cent of the people were men.
According to findings published in the BMJ, trials which used only vitamin D at a dose of 10 or 20 micrograms showed no significant reductions in fracture risk. When 10 micrograms of the vitamin was taken with calcium, however, reduced risks of fracture and hip fracture of 8 and 16 per cent, respectively. The combination was effective “irrespective of age, sex, or previous fractures”, said the researchers.
“This study supports a growing consensus that combined calcium and vitamin D is more effective than vitamin D alone in reducing a variety of fractures,” said Robbins. “Interestingly, this combination of supplements benefits both women and men of all ages, which is not something we fully expected to find. We now need to investigate the best dosage, duration and optimal way for people to take it,” he added.
Estimates suggest that in the absence of primary prevention the number of hip fractures worldwide will increase to approximately 2.6 million by the year 2025, and 4.5 million by the year 2050.
Osteoporosis weakens bone strength which increases the likelihood of hip fracture, a problem that increases with age.
Source: British Medical Journal
2010; 340: b5463 Published online, doi:10.1136/bmj.b5463 |
“Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe”
Authors: B. Abrahamsen for the DIPART (vitamin D Individual Patient Analysis of Randomized Trials) Group
Vitamin D plus calcium may protect everyone from fracture: Study
By Stephen Daniells, 15-Jan-2010
Related topics: Research, Minerals, Vitamins & premixes, Bone & joint health
Daily supplements which combine vitamin D and calcium may reduce the risk of fractures for everyone, regardless of age or gender, say the results of a huge study.
Almost 70,000 people participated in the US and Europe and found that the vitamin-mineral combination significantly reduced fractures by 8 per cent, and hip fractures by 16 per cent, according to results of a pooled analysis published in the British Medical Journal.
However, supplemental vitamin D on its own in daily doses equivalent to 10 to 20 micrograms had no effects on fracture prevention, said the study, led by researchers at Copenhagen University in Denmark.
“What is important about this very large study is that goes a long way toward resolving conflicting evidence about the role of vitamin D, either alone or in combination with calcium, in reducing fractures,” said co-author of the study, Professor John Robbins from the University of California, Davis.
History of use
The combination of vitamin D and calcium has long been recommended to reduce the risk of bone fracture for older people, particularly those at risk of or suffering from osteoporosis, which is estimated to affect about 75m people in Europe, USA and Japan.
The action of the nutrients is complimentary, with calcium supporting bone formation and repair, while vitamin D helps the body absorb calcium.
The new study reports that the bone boosting effects of vitamin D plus calcium may also extend to other age groups and to both sexes.
Study details
The researchers used data from seven major randomized trials of vitamin D with calcium or vitamin D alone, providing data from 68,517 people. The average age of the participants was 69.9, and 15 per cent of the people were men.
According to findings published in the BMJ, trials which used only vitamin D at a dose of 10 or 20 micrograms showed no significant reductions in fracture risk. When 10 micrograms of the vitamin was taken with calcium, however, reduced risks of fracture and hip fracture of 8 and 16 per cent, respectively. The combination was effective “irrespective of age, sex, or previous fractures”, said the researchers.
“This study supports a growing consensus that combined calcium and vitamin D is more effective than vitamin D alone in reducing a variety of fractures,” said Robbins. “Interestingly, this combination of supplements benefits both women and men of all ages, which is not something we fully expected to find. We now need to investigate the best dosage, duration and optimal way for people to take it,” he added.
Estimates suggest that in the absence of primary prevention the number of hip fractures worldwide will increase to approximately 2.6 million by the year 2025, and 4.5 million by the year 2050.
Osteoporosis weakens bone strength which increases the likelihood of hip fracture, a problem that increases with age.
Source: British Medical Journal
2010; 340: b5463 Published online, doi:10.1136/bmj.b5463 |
“Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe”
Authors: B. Abrahamsen for the DIPART (vitamin D Individual Patient Analysis of Randomized Trials) Group